Specific inhibition of CK2α from an anchor outside the active site

The development of selective inhibitors of protein kinases is challenging because of the significant conservation of the ATP binding site. Here, we describe a new mechanism by which the protein kinase CK2α can be selectively inhibited using features outside the ATP site. We have identified a new bin...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Brear, Paul, De Fusco, Claudia, Hadje Georgiou, Kathy, Francis-Newton, Nicola J., Stubbs, Christopher J., Sore, Hannah F., Venkitaraman, Ashok R., Abell, Chris, Spring, David R., Hyvönen, Marko
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355960/
https://ncbi.nlm.nih.gov/pubmed/28451126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02335e
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