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Specific inhibition of CK2α from an anchor outside the active site
The development of selective inhibitors of protein kinases is challenging because of the significant conservation of the ATP binding site. Here, we describe a new mechanism by which the protein kinase CK2α can be selectively inhibited using features outside the ATP site. We have identified a new bin...
Shranjeno v:
| izdano v: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Royal Society of Chemistry
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5355960/ https://ncbi.nlm.nih.gov/pubmed/28451126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02335e |
| Oznake: |
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