Novel non-ATP competitive small molecules targeting the CK2 α/β interface

Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2 plays in many cell-signaling pathways, this makes it a prime target for down regulation to fight tumour growth. Herein, we report a fragment-based approach to inhibiting the interaction between CK2α and CK2β at t...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Brear, Paul, North, Andrew, Iegre, Jessica, Hadje Georgiou, Kathy, Lubin, Alexandra, Carro, Laura, Green, William, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562204/
https://ncbi.nlm.nih.gov/pubmed/29759799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.05.011
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