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Novel non-ATP competitive small molecules targeting the CK2 α/β interface
Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2 plays in many cell-signaling pathways, this makes it a prime target for down regulation to fight tumour growth. Herein, we report a fragment-based approach to inhibiting the interaction between CK2α and CK2β at t...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Science
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6562204/ https://ncbi.nlm.nih.gov/pubmed/29759799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.05.011 |
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