Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

Transition metal catalysis has emerged as a powerful strategy to expand synthetic flexibility of protein modification. Herein, we report a cationic Ru(ii) system that enables the first example of alkyne hydrosilylation between dimethylarylsilanes and O-propargyl-functionalized proteins using a subst...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Kwan, Terence T.-L., Boutureira, Omar, Frye, Elizabeth C., Walsh, Stephen J., Gupta, Moni K., Wallace, Stephen, Wu, Yuteng, Zhang, Fengzhi, Sore, Hannah F., Galloway, Warren R. J. D., Chin, Jason W., Welch, Martin, Bernardes, Gonçalo J. L., Spring, David R.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578368/
https://ncbi.nlm.nih.gov/pubmed/28966779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc05313k
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