Sulfatase-cleavable linkers for antibody-drug conjugates

Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules. These two components are joined by a covalent linker, whose nature is critical to the efficacy and safety of the ADC. E...

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Bibliographische Detailangaben
Veröffentlicht in:Chem Sci
Hauptverfasser: Bargh, Jonathan D., Walsh, Stephen J., Isidro-Llobet, Albert, Omarjee, Soleilmane, Carroll, Jason S., Spring, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society of Chemistry 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157321/
https://ncbi.nlm.nih.gov/pubmed/34084399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc06410a
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