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Next-generation disulfide stapling: reduction and functional re-bridging all in one

Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, applicati...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Sci
Prif Awduron: Lee, Maximillian T. W., Maruani, Antoine, Baker, James R., Caddick, Stephen, Chudasama, Vijay
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580075/
https://ncbi.nlm.nih.gov/pubmed/28966772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc02666k
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