Homogeneous Bispecifics by Disulfide Bridging

[Image: see text] We report on a chemical platform to generate site-specific, homogeneous, antibody–antibody conjugates by targeting and bridging disulfide bonds. A bispecific antibody construct was produced in good yield through simple reduction and bridging of antibody fragment disulfide bonds, us...

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Bibliographic Details
Published in:Bioconjug Chem
Main Authors: Hull, Elizabeth A., Livanos, Maria, Miranda, Enrique, Smith, Mark E. B., Chester, Kerry A., Baker, James R.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458859/
https://ncbi.nlm.nih.gov/pubmed/25033024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc5002467
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