The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks

por Sirgel, Frederick A., Warren, Robin M., Böttger, Erik C., Klopper, Marisa, Victor, Thomas C., van Helden, Paul D.
Publicado 2013

Moxifloxacin Retains Antimycobacterial Activity in the Presence of gyrA Mutations

por McGrath, Marieta, Gey van Pittius, Nico C., Sirgel, Frederick A., Van Helden, Paul D., Warren, Robin M.
Publicado 2014

The pyrazinamide susceptibility breakpoint above which combination therapy fails

por Gumbo, Tawanda, Chigutsa, Emmanuel, Pasipanodya, Jotam, Visser, Marianne, van Helden, Paul D., Sirgel, Frederick A, McIlleron, Helen
Publicado 2014

Correction: The Rationale for Using Rifabutin in the Treatment of MDR and XDR Tuberculosis Outbreaks

por Sirgel, Frederick A., Warren, Robin M., Böttger, Erik C., Klopper, Marisa, Victor, Thomas C., van Helden, Paul D.
Publicado en PLoS One (2015)

Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

por Chigutsa, Emmanuel, Pasipanodya, Jotam G., Visser, Marianne E., van Helden, Paul D., Smith, Peter J., Sirgel, Frederick A., Gumbo, Tawanda, McIlleron, Helen
Publicado en Antimicrob Agents Chemother (2014)

The potential use of rifabutin for treatment of patients diagnosed with rifampicin-resistant tuberculosis

por Whitfield, Michael G, Warren, Robin M, Mathys, Vanessa, Scott, Lesley, De Vos, Elise, Stevens, Wendy, Streicher, Elizabeth M, Groenen, Guido, Sirgel, Frederick A, Van Rie, Annelies
Publicado en J Antimicrob Chemother (2018)

Moxifloxacin Population Pharmacokinetics and Model-Based Comparison of Efficacy between Moxifloxacin and Ofloxacin in African Patients

por Zvada, Simbarashe P., Denti, Paolo, Sirgel, Frederick A., Chigutsa, Emmanuel, Hatherill, Mark, Charalambous, Salome, Mungofa, Stanley, Wiesner, Lubbe, Simonsson, Ulrika S. H., Jindani, Amina, Harrison, Thomas, McIlleron, Helen M.
Publicado 2014

Minority Mycobacterium tuberculosis Genotypic Populations as an Indicator of Subsequent Phenotypic Resistance

por Engelthaler, David M., Streicher, Elizabeth M., Kelley, Erin J., Allender, Christopher J., Wiggins, Kristin, Jimenez, Dulce, Lemmer, Darrin, Vittinghoff, Eric, Theron, Grant, Sirgel, Frederick A., Warren, Robin M., Metcalfe, John Z.
Publicado en Am J Respir Cell Mol Biol (2019)

Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection

por Wasserman, Sean, Denti, Paolo, Brust, James C. M., Abdelwahab, Mahmoud, Hlungulu, Siphokazi, Wiesner, Lubbe, Norman, Jennifer, Sirgel, Frederick A., Warren, Robin M., Esmail, Aliasgar, Dheda, Keertan, Gandhi, Neel R., Meintjes, Graeme, Maartens, Gary
Publicado en Antimicrob Agents Chemother (2019)

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

por Dheda, Keertan, Lenders, Laura, Magombedze, Gesham, Srivastava, Shashikant, Raj, Prithvi, Arning, Erland, Ashcraft, Paula, Bottiglieri, Teodoro, Wainwright, Helen, Pennel, Timothy, Linegar, Anthony, Moodley, Loven, Pooran, Anil, Pasipanodya, Jotam G., Sirgel, Frederick A., van Helden, Paul D., Wakeland, Edward, Warren, Robin M., Gumbo, Tawanda
Publicado en Am J Respir Crit Care Med (2018)

Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates

por Torres, Jessica N, Paul, Lynthia V, Rodwell, Timothy C, Victor, Thomas C, Amallraja, Anu M, Elghraoui, Afif, Goodmanson, Amy P, Ramirez-Busby, Sarah M, Chawla, Ashu, Zadorozhny, Victoria, Streicher, Elizabeth M, Sirgel, Frederick A, Catanzaro, Donald, Rodrigues, Camilla, Gler, Maria Tarcela, Crudu, Valeru, Catanzaro, Antonino, Valafar, Faramarz
Publicado en Emerg Microbes Infect (2015)

Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies

por Soares de Melo, Candice, Singh, Vinayak, Myrick, Alissa, Simelane, Sandile B., Taylor, Dale, Brunschwig, Christel, Lawrence, Nina, Schnappinger, Dirk, Engelhart, Curtis A., Kumar, Anuradha, Parish, Tanya, Su, Qin, Myers, Timothy G., Boshoff, Helena I. M., Barry, Clifton E., Sirgel, Frederick A., van Helden, Paul D., Buchanan, Kirsteen I., Bayliss, Tracy, Green, Simon R., Ray, Peter C., Wyatt, Paul G., Basarab, Gregory S., Eyermann, Charles J., Chibale, Kelly, Ghorpade, Sandeep R.
Publicado en J Med Chem (2021)

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target I...

por Wilson, Colin R., Gessner, Richard K., Moosa, Atica, Seldon, Ronnett, Warner, Digby F., Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B., Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M., Barry, Clifton E., Sirgel, Frederick A., van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J., Ghorpade, Sandeep R., Chibale, Kelly
Publicado en J Med Chem (2017)