Moxifloxacin Population Pharmacokinetics and Model-Based Comparison of Efficacy between Moxifloxacin and Ofloxacin in African Patients

Pharmacokinetic exposure and the MIC of fluoroquinolones are important determinants of their efficacy against Mycobacterium tuberculosis. Population modeling was used to describe the steady-state plasma pharmacokinetics of moxifloxacin in 241 tuberculosis (TB) patients in southern Africa. Monte Carl...

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Detalhes bibliográficos
Main Authors: Zvada, Simbarashe P., Denti, Paolo, Sirgel, Frederick A., Chigutsa, Emmanuel, Hatherill, Mark, Charalambous, Salome, Mungofa, Stanley, Wiesner, Lubbe, Simonsson, Ulrika S. H., Jindani, Amina, Harrison, Thomas, McIlleron, Helen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910772/
https://ncbi.nlm.nih.gov/pubmed/24189253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01478-13
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