Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

Rationale: Acquired resistance is an important driver of multidrug-resistant tuberculosis (TB), even with good treatment adherence. However, exactly what initiates the resistance and how it arises remain poorly understood. Objectives: To identify the relationship between drug concentrations and drug...

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Библиографические подробности
Опубликовано в: :Am J Respir Crit Care Med
Главные авторы: Dheda, Keertan, Lenders, Laura, Magombedze, Gesham, Srivastava, Shashikant, Raj, Prithvi, Arning, Erland, Ashcraft, Paula, Bottiglieri, Teodoro, Wainwright, Helen, Pennel, Timothy, Linegar, Anthony, Moodley, Loven, Pooran, Anil, Pasipanodya, Jotam G., Sirgel, Frederick A., van Helden, Paul D., Wakeland, Edward, Warren, Robin M., Gumbo, Tawanda
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2018
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221573/
https://ncbi.nlm.nih.gov/pubmed/29877726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201711-2333OC
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