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Meta-Analysis of Clinical Studies Supports the Pharmacokinetic Variability Hypothesis for Acquired Drug Resistance and Failure of Antituberculosis Therapy

Background. Using hollow-fiber tuberculosis studies, we recently demonstrated that nonadherence is not a significant factor for ADR and that therapy failure only occurs after a large proportion of doses are missed. Computer-aided clinical trial simulations have suggested that isoniazid and rifampin...

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Главные авторы: Pasipanodya, Jotam G., Srivastava, Shashikant, Gumbo, Tawanda
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491771/
https://ncbi.nlm.nih.gov/pubmed/22467670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cis353
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