Linezolid Dose That Maximizes Sterilizing Effect While Minimizing Toxicity and Resistance Emergence for Tuberculosis

Linezolid has an excellent sterilizing effect in tuberculosis patients but high adverse event rates. The dose that would maximize efficacy and minimize toxicity is unknown. We performed linezolid dose-effect and dose-scheduling studies in the hollow fiber system model of tuberculosis (HFS-TB) for st...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Srivastava, Shashikant, Magombedze, Gesham, Koeuth, Thearith, Sherman, Carleton, Pasipanodya, Jotam G., Raj, Prithvi, Wakeland, Edward, Deshpande, Devyani, Gumbo, Tawanda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527615/
https://ncbi.nlm.nih.gov/pubmed/28584143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00751-17
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