Efficacy Versus Hepatotoxicity of High-dose Rifampin, Pyrazinamide, and Moxifloxacin to Shorten Tuberculosis Therapy Duration: There Is Still Fight in the Old Warriors Yet!

BACKGROUND: One approach that could increase the efficacy and reduce the duration of antituberculosis therapy is pharmacokinetics/pharmacodynamics-based optimization of doses. However, this could increase toxicity. METHODS: We mimicked the concentration-time profiles achieved by human equivalent dos...

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Опубликовано в: :Clin Infect Dis
Главные авторы: Srivastava, Shashikant, Deshpande, Devyani, Magombedze, Gesham, Gumbo, Tawanda
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
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Supplement Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260156/
https://ncbi.nlm.nih.gov/pubmed/30496465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy627
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