Artificial intelligence–derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis

BACKGROUND: In the experimental arm of the OFLOTUB trial, gatifloxacin replaced ethambutol in the standard 4-month regimen for drug-susceptible pulmonary tuberculosis. The study included a nested pharmacokinetic (PK) study. We sought to determine if PK variability played a role in patient outcomes....

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Veröffentlicht in:Clin Infect Dis
Hauptverfasser: Pasipanodya, Jotam G, Smythe, Wynand, Merle, Corinne S, Olliaro, Piero L, Deshpande, Devyani, Magombedze, Gesham, McIlleron, Helen, Gumbo, Tawanda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Supplement Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904294/
https://ncbi.nlm.nih.gov/pubmed/30496458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy610
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