Gatifloxacin Pharmacokinetics/Pharmacodynamics–based Optimal Dosing for Pulmonary and Meningeal Multidrug-resistant Tuberculosis

BACKGROUND: Gatifloxacin is used for the treatment of multidrug-resistant tuberculosis (MDR-TB). The optimal dose is unknown. METHODS: We performed a 28-day gatifloxacin hollow-fiber system model of tuberculosis (HFS-TB) study in order to identify the target exposures associated with optimal kill ra...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Deshpande, Devyani, Pasipanodya, Jotam G, Srivastava, Shashikant, Bendet, Paula, Koeuth, Thearith, Bhavnani, Sujata M, Ambrose, Paul G, Smythe, Wynand, McIlleron, Helen, Thwaites, Guy, Gumusboga, Mourad, Van Deun, Armand, Gumbo, Tawanda
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Supplement Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904296/
https://ncbi.nlm.nih.gov/pubmed/30496459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciy618
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