Linezolid Dose That Maximizes Sterilizing Effect While Minimizing Toxicity and Resistance Emergence for Tuberculosis

Linezolid has an excellent sterilizing effect in tuberculosis patients but high adverse event rates. The dose that would maximize efficacy and minimize toxicity is unknown. We performed linezolid dose-effect and dose-scheduling studies in the hollow fiber system model of tuberculosis (HFS-TB) for st...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Srivastava, Shashikant, Magombedze, Gesham, Koeuth, Thearith, Sherman, Carleton, Pasipanodya, Jotam G., Raj, Prithvi, Wakeland, Edward, Deshpande, Devyani, Gumbo, Tawanda
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527615/
https://ncbi.nlm.nih.gov/pubmed/28584143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00751-17
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