Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

The relationships between antituberculosis drug exposure and treatment effects on humans receiving multidrug therapy are complex and nonlinear. In patients on treatment, an analysis of the rate of decline in the sputum bacillary burden reveals two slopes. The first is the α-slope, which is thought t...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Chigutsa, Emmanuel, Pasipanodya, Jotam G., Visser, Marianne E., van Helden, Paul D., Smith, Peter J., Sirgel, Frederick A., Gumbo, Tawanda, McIlleron, Helen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Clinical Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291375/
https://ncbi.nlm.nih.gov/pubmed/25313213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03931-14
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