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Impact of Nonlinear Interactions of Pharmacokinetics and MICs on Sputum Bacillary Kill Rates as a Marker of Sterilizing Effect in Tuberculosis

The relationships between antituberculosis drug exposure and treatment effects on humans receiving multidrug therapy are complex and nonlinear. In patients on treatment, an analysis of the rate of decline in the sputum bacillary burden reveals two slopes. The first is the α-slope, which is thought t...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Chigutsa, Emmanuel, Pasipanodya, Jotam G., Visser, Marianne E., van Helden, Paul D., Smith, Peter J., Sirgel, Frederick A., Gumbo, Tawanda, McIlleron, Helen
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291375/
https://ncbi.nlm.nih.gov/pubmed/25313213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03931-14
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