Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates

We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1(g609a), and two canonical mutatio...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Emerg Microbes Infect
Egile Nagusiak: Torres, Jessica N, Paul, Lynthia V, Rodwell, Timothy C, Victor, Thomas C, Amallraja, Anu M, Elghraoui, Afif, Goodmanson, Amy P, Ramirez-Busby, Sarah M, Chawla, Ashu, Zadorozhny, Victoria, Streicher, Elizabeth M, Sirgel, Frederick A, Catanzaro, Donald, Rodrigues, Camilla, Gler, Maria Tarcela, Crudu, Valeru, Catanzaro, Antonino, Valafar, Faramarz
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522615/
https://ncbi.nlm.nih.gov/pubmed/26251830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2015.42
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