Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates

We report the discovery and confirmation of 23 novel mutations with previously undocumented role in isoniazid (INH) drug resistance, in catalase-peroxidase (katG) gene of Mycobacterium tuberculosis (Mtb) isolates. With these mutations, a synonymous mutation in fabG1(g609a), and two canonical mutatio...

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Detalhes bibliográficos
Publicado no:Emerg Microbes Infect
Main Authors: Torres, Jessica N, Paul, Lynthia V, Rodwell, Timothy C, Victor, Thomas C, Amallraja, Anu M, Elghraoui, Afif, Goodmanson, Amy P, Ramirez-Busby, Sarah M, Chawla, Ashu, Zadorozhny, Victoria, Streicher, Elizabeth M, Sirgel, Frederick A, Catanzaro, Donald, Rodrigues, Camilla, Gler, Maria Tarcela, Crudu, Valeru, Catanzaro, Antonino, Valafar, Faramarz
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522615/
https://ncbi.nlm.nih.gov/pubmed/26251830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emi.2015.42
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