Single Cell Glucose Uptake Assays: A Cautionary Tale

av Sinclair, Linda V., Barthelemy, Celine, Cantrell, Doreen A.
I publikationen Immunometabolism (2020)

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

av Marchingo, Julia M, Sinclair, Linda V, Howden, Andrew JM, Cantrell, Doreen A
I publikationen eLife (2020)

Single cell analysis of kynurenine and System L amino acid transport in T cells

av Sinclair, Linda V., Neyens, Damien, Ramsay, George, Taylor, Peter M., Cantrell, Doreen A.
I publikationen Nat Commun (2018)

Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation

av Sinclair, Linda V., Rolf, Julia, Emslie, Elizabeth, Shi, Yun-Bo, Taylor, Peter M., Cantrell, Doreen A.
Publicerad 2013

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs

av Rollings, Christina M., Sinclair, Linda V., Brady, Hugh J. M., Cantrell, Doreen A., Ross, Sarah H.
I publikationen Sci Signal (2018)

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

av Matthews, Sharon A., Navarro, Maria N., Sinclair, Linda V., Emslie, Elizabeth, Feijoo-Carnero, Carmen, Cantrell, Doreen A.
Publicerad 2010

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

av Navarro, Maria N., Sinclair, Linda V., Feijoo-Carnero, Carmen, Clarke, Rosemary, Matthews, Sharon A., Cantrell, Doreen A.
Publicerad 2012

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

av Finlay, David K., Sinclair, Linda V., Feijoo, Carmen, Waugh, Caryll M., Hagenbeek, Thijs J., Spits, Hergen, Cantrell, Doreen A.
Publicerad 2009

Temporal differences in the dependency on Phosphoinositide Dependent Kinase 1 distinguish the development of iNKT cells and conventional T cells

av Finlay, David K., Kelly, April P., Clarke, Rosemary, Sinclair, Linda V., Deak, Maria, Alessi, Dario R., Cantrell, Doreen A.
Publicerad 2010

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

av Howden, Andrew JM, Hukelmann, Jens L, Brenes, Alejandro, Spinelli, Laura, Sinclair, Linda V, Lamond, Angus I, Cantrell, Doreen A
I publikationen Nat Immunol (2019)

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

av Swamy, Mahima, Pathak, Shalini, Grzes, Katarzyna M., Damerow, Sebastian, Sinclair, Linda V., van Aalten, Daan M. F., Cantrell, Doreen A.
I publikationen Nat Immunol (2016)

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

av Macintyre, Andrew N., Finlay, David, Preston, Gavin, Sinclair, Linda V., Waugh, Caryll M., Tamas, Peter, Feijoo, Carmen, Okkenhaug, Klaus, Cantrell, Doreen A.
Publicerad 2011

Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking

av Sinclair, Linda V, Finlay, David, Feijoo, Carmen, Cornish, Georgina H, Gray, Alex, Ager, Ann, Okkenhaug, Klaus, Hagenbeek, Thijs J, Spits, Hergen, Cantrell, Doreen A
Publicerad 2008

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8(+) T cells

av Finlay, David K., Rosenzweig, Ella, Sinclair, Linda V., Feijoo-Carnero, Carmen, Hukelmann, Jens L., Rolf, Julia, Panteleyev, Andrey A., Okkenhaug, Klaus, Cantrell, Doreen A.
Publicerad 2012

Glucose represses dendritic cell-induced T cell responses

av Lawless, Simon J., Kedia-Mehta, Nidhi, Walls, Jessica F., McGarrigle, Ryan, Convery, Orla, Sinclair, Linda V., Navarro, Maria N., Murray, James, Finlay, David K.
I publikationen Nat Commun (2017)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

av Preston, Gavin C, Sinclair, Linda V, Kaskar, Aneesa, Hukelmann, Jens L, Navarro, Maria N, Ferrero, Isabel, MacDonald, H Robson, Cowling, Victoria H, Cantrell, Doreen A
I publikationen EMBO J (2015)

The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin

av Hukelmann, Jens L., Anderson, Karen E., Sinclair, Linda V., Grzes, Katarzyna M., Murillo, Alejandro Brenes, Hawkins, Phillip T., Stephens, Len R., Lamond, Angus I., Cantrell, Doreen A.
I publikationen Nat Immunol (2015)

Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

av Villegas-Mendez, Ana, Khandelwal, Garima, McGowan, Lucy M., Dookie, Rebecca S., Haley, Michael J., George, Charlotte, Sims, David, Lord, Graham M., Sinclair, Linda V., Jenner, Richard G., Couper, Kevin N.
I publikationen J Immunol (2020)

Antigen receptor control of methionine metabolism in T cells

av Sinclair, Linda V, Howden, Andrew JM, Brenes, Alejandro, Spinelli, Laura, Hukelmann, Jens L, Macintyre, Andrew N, Liu, Xiaojing, Thomson, Sarah, Taylor, Peter M, Rathmell, Jeffrey C, Locasale, Jason W, Lamond, Angus I, Cantrell, Doreen A
I publikationen eLife (2019)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

av Loftus, Róisín M., Assmann, Nadine, Kedia-Mehta, Nidhi, O’Brien, Katie L., Garcia, Arianne, Gillespie, Conor, Hukelmann, Jens L., Oefner, Peter J., Lamond, Angus I., Gardiner, Clair M., Dettmer, Katja, Cantrell, Doreen A., Sinclair, Linda V., Finlay, David K.
I publikationen Nat Commun (2018)