Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL function has not been determined. Here we have shown...

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Detalhes bibliográficos
Main Authors: Macintyre, Andrew N., Finlay, David, Preston, Gavin, Sinclair, Linda V., Waugh, Caryll M., Tamas, Peter, Feijoo, Carmen, Okkenhaug, Klaus, Cantrell, Doreen A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052433/
https://ncbi.nlm.nih.gov/pubmed/21295499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.01.012
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