Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking

PI3K and mTOR are evolutionarily conserved regulators of cell metabolism. Here we show PI3K and mTOR determine the repertoire of adhesion and chemokine receptors expressed by T lymphocytes. Key lymph node homing receptors, CD62L (L-selectin) and CCR7, are highly expressed on naive T lymphocytes but...

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Detalhes bibliográficos
Main Authors: Sinclair, Linda V, Finlay, David, Feijoo, Carmen, Cornish, Georgina H, Gray, Alex, Ager, Ann, Okkenhaug, Klaus, Hagenbeek, Thijs J, Spits, Hergen, Cantrell, Doreen A
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857321/
https://ncbi.nlm.nih.gov/pubmed/18391955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1603
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