Single Cell Glucose Uptake Assays: A Cautionary Tale

Por Sinclair, Linda V., Barthelemy, Celine, Cantrell, Doreen A.
Publicado no Immunometabolism (2020)

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

Por Marchingo, Julia M, Sinclair, Linda V, Howden, Andrew JM, Cantrell, Doreen A
Publicado no eLife (2020)

Single cell analysis of kynurenine and System L amino acid transport in T cells

Por Sinclair, Linda V., Neyens, Damien, Ramsay, George, Taylor, Peter M., Cantrell, Doreen A.
Publicado no Nat Commun (2018)

Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation

Por Sinclair, Linda V., Rolf, Julia, Emslie, Elizabeth, Shi, Yun-Bo, Taylor, Peter M., Cantrell, Doreen A.
Publicado em 2013

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs

Por Rollings, Christina M., Sinclair, Linda V., Brady, Hugh J. M., Cantrell, Doreen A., Ross, Sarah H.
Publicado no Sci Signal (2018)

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Por Matthews, Sharon A., Navarro, Maria N., Sinclair, Linda V., Emslie, Elizabeth, Feijoo-Carnero, Carmen, Cantrell, Doreen A.
Publicado em 2010

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Por Navarro, Maria N., Sinclair, Linda V., Feijoo-Carnero, Carmen, Clarke, Rosemary, Matthews, Sharon A., Cantrell, Doreen A.
Publicado em 2012

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

Por Finlay, David K., Sinclair, Linda V., Feijoo, Carmen, Waugh, Caryll M., Hagenbeek, Thijs J., Spits, Hergen, Cantrell, Doreen A.
Publicado em 2009

Temporal differences in the dependency on Phosphoinositide Dependent Kinase 1 distinguish the development of iNKT cells and conventional T cells

Por Finlay, David K., Kelly, April P., Clarke, Rosemary, Sinclair, Linda V., Deak, Maria, Alessi, Dario R., Cantrell, Doreen A.
Publicado em 2010

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

Por Howden, Andrew JM, Hukelmann, Jens L, Brenes, Alejandro, Spinelli, Laura, Sinclair, Linda V, Lamond, Angus I, Cantrell, Doreen A
Publicado no Nat Immunol (2019)

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Por Swamy, Mahima, Pathak, Shalini, Grzes, Katarzyna M., Damerow, Sebastian, Sinclair, Linda V., van Aalten, Daan M. F., Cantrell, Doreen A.
Publicado no Nat Immunol (2016)

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

Por Macintyre, Andrew N., Finlay, David, Preston, Gavin, Sinclair, Linda V., Waugh, Caryll M., Tamas, Peter, Feijoo, Carmen, Okkenhaug, Klaus, Cantrell, Doreen A.
Publicado em 2011

Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of rapamycin) pathways control T lymphocyte trafficking

Por Sinclair, Linda V, Finlay, David, Feijoo, Carmen, Cornish, Georgina H, Gray, Alex, Ager, Ann, Okkenhaug, Klaus, Hagenbeek, Thijs J, Spits, Hergen, Cantrell, Doreen A
Publicado em 2008

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8(+) T cells

Por Finlay, David K., Rosenzweig, Ella, Sinclair, Linda V., Feijoo-Carnero, Carmen, Hukelmann, Jens L., Rolf, Julia, Panteleyev, Andrey A., Okkenhaug, Klaus, Cantrell, Doreen A.
Publicado em 2012

Glucose represses dendritic cell-induced T cell responses

Por Lawless, Simon J., Kedia-Mehta, Nidhi, Walls, Jessica F., McGarrigle, Ryan, Convery, Orla, Sinclair, Linda V., Navarro, Maria N., Murray, James, Finlay, David K.
Publicado no Nat Commun (2017)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Por Preston, Gavin C, Sinclair, Linda V, Kaskar, Aneesa, Hukelmann, Jens L, Navarro, Maria N, Ferrero, Isabel, MacDonald, H Robson, Cowling, Victoria H, Cantrell, Doreen A
Publicado no EMBO J (2015)

The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin

Por Hukelmann, Jens L., Anderson, Karen E., Sinclair, Linda V., Grzes, Katarzyna M., Murillo, Alejandro Brenes, Hawkins, Phillip T., Stephens, Len R., Lamond, Angus I., Cantrell, Doreen A.
Publicado no Nat Immunol (2015)

Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

Por Villegas-Mendez, Ana, Khandelwal, Garima, McGowan, Lucy M., Dookie, Rebecca S., Haley, Michael J., George, Charlotte, Sims, David, Lord, Graham M., Sinclair, Linda V., Jenner, Richard G., Couper, Kevin N.
Publicado no J Immunol (2020)

Antigen receptor control of methionine metabolism in T cells

Por Sinclair, Linda V, Howden, Andrew JM, Brenes, Alejandro, Spinelli, Laura, Hukelmann, Jens L, Macintyre, Andrew N, Liu, Xiaojing, Thomson, Sarah, Taylor, Peter M, Rathmell, Jeffrey C, Locasale, Jason W, Lamond, Angus I, Cantrell, Doreen A
Publicado no eLife (2019)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Por Loftus, Róisín M., Assmann, Nadine, Kedia-Mehta, Nidhi, O’Brien, Katie L., Garcia, Arianne, Gillespie, Conor, Hukelmann, Jens L., Oefner, Peter J., Lamond, Angus I., Gardiner, Clair M., Dettmer, Katja, Cantrell, Doreen A., Sinclair, Linda V., Finlay, David K.
Publicado no Nat Commun (2018)