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Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We now show that glutamine and glucose also fuel an indispensible dynamic regulation of intracellular protein O-GlcNAcylation at key stages of T cell development, transf...
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| Publicado no: | Nat Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4900450/ https://ncbi.nlm.nih.gov/pubmed/27111141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3439 |
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