More Paths to PI3Kγ

Autor Stephens, Len, Hawkins, Phillip
Vydáno 2013

9. Successful use of IL-6 pathway blockade to treat autoinflammation occurring in the context of a novel TNFRS1A gene mutation

Autor Dyke, Bernard, Gordon, Caroline, Hawkins, Phillip, Tosounidou, Sofia
Vydáno v Rheumatol Adv Pract (2019)

How is the acyl chain composition of phosphoinositides created and does it matter?

Autor Barneda, David, Cosulich, Sabina, Stephens, Len, Hawkins, Phillip
Vydáno v Biochem Soc Trans (2019)

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment

Autor Gyori, David, Chessa, Tamara, Hawkins, Phillip T., Stephens, Len R.
Vydáno v Cancers (Basel) (2017)

3D time series analysis of cell shape using Laplacian approaches

Autor Du, Cheng-Jin, Hawkins, Phillip T, Stephens, Len R, Bretschneider, Till
Vydáno 2013

PtdIns3P binding to the PX domain of p40(phox) is a physiological signal in NADPH oxidase activation

Autor Ellson, Chris, Davidson, Keith, Anderson, Karen, Stephens, Len R, Hawkins, Phillip T
Vydáno 2006

Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells

Autor Anderson, Karen E., Juvin, Veronique, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T.
Vydáno v Adv Biol Regul (2016)

Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits.

Autor Krugmann, Sonja, Cooper, Matthew A, Williams, Dudley H, Hawkins, Phillip T, Stephens, Len R
Vydáno 2002

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

Autor Li, Zuomei, Wahl, Matthew I., Eguinoa, Alicia, Stephens, Leonard R., Hawkins, Phillip T., Witte, Owen N.
Vydáno 1997

Neutrophils from p40(phox−/−) mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing

Autor Ellson, Chris D., Davidson, Keith, Ferguson, G. John, O'Connor, Rod, Stephens, Len R., Hawkins, Phillip T.
Vydáno 2006

Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop

Autor Kiselev, Vladimir Yu., Juvin, Veronique, Malek, Mouhannad, Luscombe, Nicholas, Hawkins, Phillip, Novère, Nicolas Le, Stephens, Len
Vydáno v Nucleic Acids Res (2015)

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells

Autor Ross, Sarah H., Rollings, Christina, Anderson, Karen E., Hawkins, Phillip T., Stephens, Len R., Cantrell, Doreen A.
Vydáno v Immunity (2016)

Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP(2) in the Mouse

Autor Anderson, Karen E., Kielkowska, Anna, Durrant, Tom N., Juvin, Veronique, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T.
Vydáno 2013

Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses

Autor Suire, Sabine, Baltanas, Fernando C., Segonds‐Pichon, Anne, Davidson, Keith, Santos, Eugenio, Hawkins, Phillip T., Stephens, Len R.
Vydáno v J Leukoc Biol (2019)

Phosphorylation of threonine 154 in p40(phox) is an important physiological signal for activation of the neutrophil NADPH oxidase

Autor Chessa, Tamara A. M., Anderson, Karen E., Hu, Yanhua, Xu, Qingbo, Rausch, Oliver, Stephens, Len R., Hawkins, Phillip T.
Vydáno 2010

Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling

Autor Clark, Jonathan, Kay, Robert R, Kielkowska, Anna, Niewczas, Izabella, Fets, Louise, Oxley, David, Stephens, Len R, Hawkins, Phillip T
Vydáno v EMBO J (2014)

PI3K regulates integrin-dependent processes in neutrophils by signalling through its effector ARAP3

Autor Gambardella, Laure, Anderson, Karen E., Jakus, Zoltán, Kovács, Miklós, Voigt, Susann, Hawkins, Phillip T., Stephens, Len, Mócsai, Attila, Vermeren, Sonja
Vydáno 2012

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Autor Zhang, Xuxiao, Vadas, Oscar, Perisic, Olga, Anderson, Karen E., Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R., Williams, Roger L.
Vydáno 2011

Two distinct functions for PI3-kinases in macropinocytosis

Autor Hoeller, Oliver, Bolourani, Parvin, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T., Weiner, Orion D., Weeks, Gerald, Kay, Robert R.
Vydáno 2013

In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P(2) to impact mTORC2 and Akt signaling

Autor Bulley, Simon J., Droubi, Alaa, Clarke, Jonathan H., Anderson, Karen E., Stephens, Len R., Hawkins, Phillip T., Irvine, Robin F.
Vydáno v Proc Natl Acad Sci U S A (2016)