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PI3K regulates integrin-dependent processes in neutrophils by signalling through its effector ARAP3
ARAP3, a GTPase activating protein for Rho and Arf family GTPases, is one of many PI3K effectors. Here we investigate the regulatory input of PI3K upstream of ARAP3, by analysing neutrophils from an ARAP3 PH domain point mutation knock-in mouse (R302, 303A), in which ARAP3 is uncoupled from activati...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672969/ https://ncbi.nlm.nih.gov/pubmed/23180820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201330 |
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