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Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

β(2) integrins and Fcγ receptors are critically involved in neutrophil activation at the site of inflammation. Both receptor types trigger a receptor-proximal tyrosine phosphorylation cascade through Src family kinases and Syk, but further downstream signaling events are poorly understood. We show t...

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Main Authors: Jakus, Zoltán, Simon, Edina, Frommhold, David, Sperandio, Markus, Mócsai, Attila
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699137/
https://ncbi.nlm.nih.gov/pubmed/19273622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081859
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