In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P(2) to impact mTORC2 and Akt signaling

Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are enigmatic lipid kinases with physiological functions that are incompletely understood, not the least because genetic deletion and cell transfection have led to contradictory data. Here, we used the genetic tractability of DT40 cells to create...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bulley, Simon J., Droubi, Alaa, Clarke, Jonathan H., Anderson, Karen E., Stephens, Len R., Hawkins, Phillip T., Irvine, Robin F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035885/
https://ncbi.nlm.nih.gov/pubmed/27601656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522478113
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