Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

mTORC2 (mammalian target of rapamycin complex 2) plays important roles in signal transduction by regulating an array of downstream effectors, including protein kinase AKT. However, its regulation by upstream regulators remains poorly characterized. Although phosphatidylinositol 3,4,5-trisphosphate (...

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Bibliografiske detaljer
Main Authors: Gan, Xiaoqing, Wang, Jiyong, Su, Bing, Wu, Dianqing
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064154/
https://ncbi.nlm.nih.gov/pubmed/21310961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195016
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