Phosphoinositide-dependent Protein Kinase (PDK) Activity Regulates Phosphatidylinositol 3,4,5-Trisphosphate-dependent and -independent Protein Kinase B Activation and Chemotaxis

Chemotactic cells must sense shallow extracellular gradients and produce localized intracellular responses. We previously showed that the temporal and spatial activation of two protein kinase B (PKB) homologues, PkbA and PkbR1, in Dictyostelium discoideum by phosphorylation of activation loops (ALs)...

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Detalhes bibliográficos
Main Authors: Kamimura, Yoichiro, Devreotes, Peter N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832944/
https://ncbi.nlm.nih.gov/pubmed/20075071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.089235
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