PtdIns(3,4,5)P(3)-dependent Activation of the mTORC2 Kinase Complex

mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation by growth factors and amino acids have been extensively studied, the upstream regulatory mechanisms leading to mTORC2 activation remain larg...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Liu, Pengda, Gan, Wenjian, Chin, Y. Rebecca, Ogura, Kohei, Guo, Jianping, Zhang, Jinfang, Wang, Bin, Blenis, John, Cantley, Lewis C., Toker, Alex, Su, Bing, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631654/
https://ncbi.nlm.nih.gov/pubmed/26293922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0460
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