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PtdIns3P controls mTORC1 signaling through lysosomal positioning
The mechanistic target of rapamycin complex 1 (mTORC1) is a protein kinase complex that localizes to lysosomes to up-regulate anabolic processes and down-regulate autophagy. Although mTORC1 is known to be activated by lysosome positioning and by amino acid–stimulated production of phosphatidylinosit...
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| Publicado en: | J Cell Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5716264/ https://ncbi.nlm.nih.gov/pubmed/29030394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201611073 |
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