PtdIns(3,4,5)P(3)-dependent Activation of the mTORC2 Kinase Complex

mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation by growth factors and amino acids have been extensively studied, the upstream regulatory mechanisms leading to mTORC2 activation remain larg...

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Vydáno v:Cancer Discov
Hlavní autoři: Liu, Pengda, Gan, Wenjian, Chin, Y. Rebecca, Ogura, Kohei, Guo, Jianping, Zhang, Jinfang, Wang, Bin, Blenis, John, Cantley, Lewis C., Toker, Alex, Su, Bing, Wei, Wenyi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631654/
https://ncbi.nlm.nih.gov/pubmed/26293922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0460
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