Phagosomal membrane targeting of Irgm1 via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes mycobacterial immunity

Vertebrate immunity to infection enlists a new family of 47 kDa immunity-related GTPases (IRGs). One IRG in particular - Irgm1 - is essential for macrophage host defense against phagosomal pathogens including Mycobacterium tuberculosis (Mtb). Here we show Irgm1 targets the mycobacterial phagosome (P...

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Main Authors: Tiwari, Sangeeta, Choi, Han-Pil, Matsuzawa, Takeshi, Pypaert, Marc, MacMicking, John D.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715447/
https://ncbi.nlm.nih.gov/pubmed/19620982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1759
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