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Phagosomal membrane targeting of Irgm1 via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes mycobacterial immunity
Vertebrate immunity to infection enlists a new family of 47 kDa immunity-related GTPases (IRGs). One IRG in particular - Irgm1 - is essential for macrophage host defense against phagosomal pathogens including Mycobacterium tuberculosis (Mtb). Here we show Irgm1 targets the mycobacterial phagosome (P...
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| Main Authors: | , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2009
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715447/ https://ncbi.nlm.nih.gov/pubmed/19620982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1759 |
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