Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits.

Type IB phosphoinositide 3OH-kinase (PI3K) is activated by G-protein betagamma subunits (Gbetagammas). The enzyme is soluble and largely cytosolic in vivo. Its substrate, PtdIns(4,5)P(2), and the Gbetagammas are localized at the plasma membrane. We have addressed the mechanism by which Gbetagammas r...

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Bibliografske podrobnosti
Main Authors: Krugmann, Sonja, Cooper, Matthew A, Williams, Dudley H, Hawkins, Phillip T, Stephens, Len R
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222438/
https://ncbi.nlm.nih.gov/pubmed/11879201
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