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Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP(2) in the Mouse
We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular phosphoinositide content. LPIAT1(−/−) mice were born at lower than Mendelian ratios and exhibited a severe developmental brain defect. We com...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3589398/ https://ncbi.nlm.nih.gov/pubmed/23472195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058425 |
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