Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP(2) in the Mouse

We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular phosphoinositide content. LPIAT1(−/−) mice were born at lower than Mendelian ratios and exhibited a severe developmental brain defect. We com...

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Bibliografiske detaljer
Main Authors: Anderson, Karen E., Kielkowska, Anna, Durrant, Tom N., Juvin, Veronique, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589398/
https://ncbi.nlm.nih.gov/pubmed/23472195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058425
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