How is the acyl chain composition of phosphoinositides created and does it matter?

著者: Barneda, David, Cosulich, Sabina, Stephens, Len, Hawkins, Phillip
出版年 Biochem Soc Trans (2019)

Genome-Wide Estrogen Receptor Activity in Breast Cancer

著者: Farcas, Anca M, Nagarajan, Sankari, Cosulich, Sabina, Carroll, Jason S
出版年 Endocrinology (2020)

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

著者: García-Martínez, Juan M., Moran, Jennifer, Clarke, Rosemary G., Gray, Alex, Cosulich, Sabina C., Chresta, Christine M., Alessi, Dario R.
出版事項 2009

Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines

著者: Juvin, Veronique, Malek, Mouhannad, Anderson, Karen E., Dion, Carine, Chessa, Tamara, Lecureuil, Charlotte, Ferguson, G. John, Cosulich, Sabina, Hawkins, Phillip T., Stephens, Len R.
出版事項 2013

Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models

著者: Wong Te Fong, Anne-Christine, Thavasu, Parames, Gagrica, Sladjana, Swales, Karen E., Leach, Martin O., Cosulich, Sabina C., Chung, Yuen-Li, Banerji, Udai
出版年 Oncotarget (2017)

Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity

著者: Langdon, Sophie, Hughes, Adina, Taylor, Molly A., Kuczynski, Elizabeth A., Mele, Deanna A., Delpuech, Oona, Jarvis, Laura, Staniszewska, Anna, Cosulich, Sabina, Carnevalli, Larissa S., Sinclair, Charles
出版年 Oncoimmunology (2018)

Combined inhibition of mTOR and CDK4/6 is required for optimal blockade of E2F function and long term growth inhibition in estrogen receptor positive breast cancer

著者: Michaloglou, Chrysiis, Crafter, Claire, Siersbæk, Rasmus, Delpuech, Oona, Curwen, Jon, Carnevalli, Larissa S., Staniszewska, Anna D., Polanska, Urszula M., Cheraghchi-Bashi, Azadeh, Lawson, Mandy, Chernukhin, Igor, McEwen, Robert, Carroll, Jason S., Cosulich, Sabina C.
出版年 Mol Cancer Ther (2018)

Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers

著者: Hatem, Rana, Botty, Rania El, Chateau-Joubert, Sophie, Servely, Jean-Luc, Labiod, Dalila, de Plater, Ludmilla, Assayag, Franck, Coussy, Florence, Callens, Céline, Vacher, Sophie, Reyal, Fabien, Cosulich, Sabina, Diéras, Véronique, Bièche, Ivan, Marangoni, Elisabetta
出版年 Oncotarget (2016)

Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

著者: Pancholi, Sunil, Leal, Mariana Ferreira, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Chateau-Joubert, Sophie, Zabaglo, Lila, Hills, Margaret, Dodson, Andrew, Gao, Qiong, Johnston, Stephen R., Dowsett, Mitch, Cosulich, Sabina C., Maragoni, Elisabetta, Martin, Lesley-Ann
出版年 Breast Cancer Res (2019)

Correction to: Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

著者: Pancholi, Sunil, Leal, Mariana Ferreira, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Chateau-Joubert, Sophie, Zabaglo, Lila, Hills, Margaret, Dodson, Andrew, Gao, Qiong, Johnston, Stephen R., Dowsett, Mitch, Cosulich, Sabina C., Marangoni, Elisabetta, Martin, Lesley-Ann
出版年 Breast Cancer Res (2020)

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor

著者: Rodrik-Outmezguine, Vanessa S., Okaniwa, Masanori, Yao, Zhan, Novotny, Chris J., McWhirter, Claire, Banaji, Arpitha, Won, Helen, Wong, Wai, Berger, Mike, de Stanchina, Elisa, Barratt, Derek G., Cosulich, Sabina, Klinowska, Teresa, Rosen, Neal, Shokat, Kevan M.
出版年 Nature (2016)

Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma

著者: Cumberbatch, Marie, Tang, Ximing, Beran, Garry, Eckersley, Sonia, Wang, Xin, Ellston, Rebecca P.A., Dearden, Simon, Cosulich, Sabina, Smith, Paul D., Behrens, Carmen, Kim, Edward S., Su, Xinying, Fan, Shuqiong, Gray, Neil, Blowers, David P., Wistuba, Ignacio I., Womack, Chris
出版年 Clin Cancer Res (2013)

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

著者: Guillermet-Guibert, Julie, Smith, Lee B., Halet, Guillaume, Whitehead, Maria A., Pearce, Wayne, Rebourcet, Diane, León, Kelly, Crépieux, Pascale, Nock, Gemma, Strömstedt, Maria, Enerback, Malin, Chelala, Claude, Graupera, Mariona, Carroll, John, Cosulich, Sabina, Saunders, Philippa T. K., Huhtaniemi, Ilpo, Vanhaesebroeck, Bart
出版年 PLoS Genet (2015)

AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival

著者: Cosimo, Emilio, Tarafdar, Anuradha, Moles, Michael W., Holroyd, Ailsa K., Malik, Natasha, Catherwood, Mark A., Hay, Jodie, Dunn, Karen M., Macdonald, Alan M., Guichard, Sylvie M., O’Rourke, Declan, Leach, Michael T., Sansom, Owen J., Cosulich, Sabina C., McCaig, Alison M., Michie, Alison M.
出版年 Clin Cancer Res (2018)

MYC-driven small cell lung cancer is metabolically distinct and vulnerable to arginine depletion

著者: Chalishazar, Milind D., Wait, Sarah J., Huang, Fang, Ireland, Abbie S., Mukhopadhyay, Anandaroop, Lee, Younjee, Schuman, Sophia S., Guthrie, Matthew R., Berrett, Kristofer C., Vahrenkamp, Jeffery, Hu, Zeping, Kudla, Marek, Modzelewska, Katarzyna, Wang, Guoying, Ingolia, Nicholas T., Gertz, Jason, Lum, David H., Cosulich, Sabina C., Bomalaski, John, DeBerardinis, Ralph J., Oliver, Trudy G.
出版年 Clin Cancer Res (2019)

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

著者: Georgopoulou, Dimitra, Callari, Maurizio, Rueda, Oscar M., Shea, Abigail, Martin, Alistair, Giovannetti, Agnese, Qosaj, Fatime, Dariush, Ali, Chin, Suet-Feung, Carnevalli, Larissa S., Provenzano, Elena, Greenwood, Wendy, Lerda, Giulia, Esmaeilishirazifard, Elham, O’Reilly, Martin, Serra, Violeta, Bressan, Dario, Mills, Gordon B., Ali, H. Raza, Cosulich, Sabina S., Hannon, Gregory J., Bruna, Alejandra, Caldas, Carlos
出版年 Nat Commun (2021)

PTEN Regulates PI(3,4)P(2) Signaling Downstream of Class I PI3K

著者: Malek, Mouhannad, Kielkowska, Anna, Chessa, Tamara, Anderson, Karen E., Barneda, David, Pir, Pınar, Nakanishi, Hiroki, Eguchi, Satoshi, Koizumi, Atsushi, Sasaki, Junko, Juvin, Véronique, Kiselev, Vladimir Y., Niewczas, Izabella, Gray, Alexander, Valayer, Alexandre, Spensberger, Dominik, Imbert, Marine, Felisbino, Sergio, Habuchi, Tomonori, Beinke, Soren, Cosulich, Sabina, Le Novère, Nicolas, Sasaki, Takehiko, Clark, Jonathan, Hawkins, Phillip T., Stephens, Len R.
出版年 Mol Cell (2017)