Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models

Activation of the PI3K/mTOR pathway has been shown to be correlated with resistance to chemotherapy in ovarian cancer. We aimed to investigate the effects of combining inhibition of mTORC1 and 2 using the mTOR kinase inhibitor vistusertib (AZD2014) with paclitaxel in in vitro and in vivo ovarian can...

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Udgivet i:Oncotarget
Main Authors: Wong Te Fong, Anne-Christine, Thavasu, Parames, Gagrica, Sladjana, Swales, Karen E., Leach, Martin O., Cosulich, Sabina C., Chung, Yuen-Li, Banerji, Udai
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768370/
https://ncbi.nlm.nih.gov/pubmed/29371953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23022
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