Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection

BACKGROUND: Little is known about how new generation adenosine triphosphate (ATP)-competitive mechanistic target of rapamycin (mTOR) kinase inhibitors (TORKinibs) affect immunity and allograft rejection. METHODS: mTOR complex (C) 1 and 2 signaling in dendritic cells (DC) and T cells was analyzed by...

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Udgivet i:Transplantation
Main Authors: Fantus, Daniel, Dai, Helong, Ono, Yoshihiro, Watson, Alicia, Yokota, Shinichiro, Mohib, Kanishka, Yoshida, Osamu, Ross, Mark A., Watkins, Simon C., Ramaswami, Bala, Valusjkikh, Anna, Rothstein, David M., Thomson, Angus W.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709200/
https://ncbi.nlm.nih.gov/pubmed/28885497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001933
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