AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast...

by Mu, Zhaomei, Klinowska, Teresa, Dong, Xiaoshen, Foster, Emily, Womack, Chris, Fernandez, Sandra V, Cristofanilli, Massimo
Published 2014

HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

by Tracey, Natasha, Creedon, Helen, Kemp, Alain J., Culley, Jayne, Muir, Morwenna, Klinowska, Teresa, Brunton, Valerie G.
Published in Breast Cancer Res Treat (2019)

Combining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer...

by CRAFTER, CLAIRE, VINCENT, JOHN P., TANG, ERIC, DUDLEY, PHILLIPPA, JAMES, NEIL H., KLINOWSKA, TERESA, DAVIES, BARRY R.
Published in Int J Oncol (2015)

THERAPEUTIC POTENTIAL OF THE DUAL EGFR/HER2 INHIBITOR AZD8931 IN CIRCUMVENTING ENDOCRINE RESISTANCE

by Morrison, Gladys, Fu, Xiaoyong, Shea, Marty, Nanda, Sarmistha, Giuliano, Mario, Wang, Tao, Klinowska, Teresa, Osborne, C. Kent, Rimawi, Mothaffar F., Schiff, Rachel
Published 2014

Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer

by Creedon, Helen, Balderstone, Lucy A., Muir, Morwenna, Balla, Jozef, Gomez-Cuadrado, Laura, Tracey, Natasha, Loane, Joseph, Klinowska, Teresa, Muller, William J., Brunton, Valerie G.
Published in Dis Model Mech (2016)

Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland

by Metcalfe, Anthony D., Gilmore, Andrew, Klinowska, Teresa, Oliver, Janine, Valentijn, Anthony J., Brown, Robin, Ross, Andrea, MacGregor, Grant, Hickman, John A., Streuli, Charles H.
Published 1999

Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation

by Hennessy, Edward J., Chuaqui, Claudio, Ashton, Susan, Colclough, Nicola, Cross, Darren A. E., Debreczeni, Judit É., Eberlein, Cath, Gingipalli, Lakshmaiah, Klinowska, Teresa C. M., Orme, Jonathan P., Sha, Li, Wu, Xiaoyun
Published in ACS Med Chem Lett (2016)

Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry

by Scott, James S., Breed, Jason, Carbajo, Rodrigo J., Davey, Paul R., Greenwood, Ryan, Huynh, Hoan K., Klinowska, Teresa, Morrow, Christopher J., Moss, Thomas A., Polanski, Radoslaw, Nissink, J. Willem M., Varnes, Jeffrey, Yang, Bin
Published in ACS Med Chem Lett (2019)

Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors

by Barlaam, Bernard, Anderton, Judith, Ballard, Peter, Bradbury, Robert H., Hennequin, Laurent F. A., Hickinson, D. Mark, Kettle, Jason G., Kirk, George, Klinowska, Teresa, Lambert-van der Brempt, Christine, Trigwell, Cath, Vincent, John, Ogilvie, Donald
Published 2013

Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor

by Rodrik-Outmezguine, Vanessa S., Okaniwa, Masanori, Yao, Zhan, Novotny, Chris J., McWhirter, Claire, Banaji, Arpitha, Won, Helen, Wong, Wai, Berger, Mike, de Stanchina, Elisa, Barratt, Derek G., Cosulich, Sabina, Klinowska, Teresa, Rosen, Neal, Shokat, Kevan M.
Published in Nature (2016)

Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy

by Creedon, Helen, Gómez-Cuadrado, Laura, Tarnauskaitė, Žygimantė, Balla, Jozef, Canel, Marta, MacLeod, Kenneth G., Serrels, Bryan, Fraser, Craig, Unciti-Broceta, Asier, Tracey, Natasha, Le Bihan, Thierry, Klinowska, Teresa, Sims, Andrew H., Byron, Adam, Brunton, Valerie G.
Published in Oncotarget (2016)

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

by Cross, Darren A. E., Ashton, Susan E., Ghiorghiu, Serban, Eberlein, Cath, Nebhan, Caroline A., Spitzler, Paula J., Orme, Jonathon P., Finlay, M. Raymond V., Ward, Richard A., Mellor, Martine J., Hughes, Gareth, Rahi, Amar, Jacobs, Vivien N., Brewer, Monica Red, Ichihara, Eiki, Sun, Jing, Jin, Hailing, Ballard, Peter, Al-Kadhimi, Katherine, Rowlinson, Rachel, Klinowska, Teresa, Richmond, Graham H. P., Cantarini, Mireille, Kim, Dong-Wan, Ranson, Malcolm R., Pao, William
Published in Cancer Discov (2014)

Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-a...

by Fu, Xiaoyong, Creighton, Chad J, Biswal, Nrusingh C, Kumar, Vijetha, Shea, Martin, Herrera, Sabrina, Contreras, Alejandro, Gutierrez, Carolina, Wang, Tao, Nanda, Sarmistha, Giuliano, Mario, Morrison, Gladys, Nardone, Agostina, Karlin, Kristen L, Westbrook, Thomas F, Heiser, Laura M, Anur, Pavana, Spellman, Paul, Guichard, Sylvie M, Smith, Paul D, Davies, Barry R, Klinowska, Teresa, Lee, Adrian V, Mills, Gordon B, Rimawi, Mothaffar F, Hilsenbeck, Susan G, Gray, Joe W, Joshi, Amit, Osborne, C Kent, Schiff, Rachel
Published in Breast Cancer Res (2014)