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Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity
mTOR inhibition can promote or inhibit immune responses in a context dependent manner, but whether this will represent a net benefit or be contraindicated in the context of immunooncology therapies is less understood. Here, we report that the mTORC1/2 dual kinase inhibitor vistusertib (AZD2014) pote...
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| 發表在: | Oncoimmunology |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6136876/ https://ncbi.nlm.nih.gov/pubmed/30221055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1458810 |
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