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Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)–mediated phosphorylation and activation of protein kinase B (PKB) is essential for the phosphorylation and inactivation of Foxo family transcription factors, and also controls T cell growth and proliferation. The current study...

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Bibliografiske detaljer
Main Authors: Finlay, David K., Sinclair, Linda V., Feijoo, Carmen, Waugh, Caryll M., Hagenbeek, Thijs J., Spits, Hergen, Cantrell, Doreen A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768858/
https://ncbi.nlm.nih.gov/pubmed/19808258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090219
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