Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

The present study explored the consequences of phosphoinositide (3,4,5)-triphosphate [PI(3,4,5)P(3)] binding to the pleckstrin homology (PH) domain of the serine/threonine kinase 3-phosphoinositide-dependent kinase 1 (PDK1). The salient finding is that PDK1 directly transduces the PI(3,4,5)P(3) sign...

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Bibliographic Details
Main Authors: Waugh, Caryll, Sinclair, Linda, Finlay, David, Bayascas, Jose R., Cantrell, Doreen
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772752/
https://ncbi.nlm.nih.gov/pubmed/19703999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00585-09
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