O(6)-Methylguanine-DNA methyltransferase deficiency in developing brain: Implications for brain tumorigenesis

Por Bobola, Michael S., Blank, A., Berger, Mitchel S., Silber, John R.
Publicado em 2007

Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression

Por Bobola, Michael S., Kolstoe, Douglas D., Blank, A., Silber, John R.
Publicado em 2010

O(6)-methylguanine-DNA methyltransferase in glioma therapy: Promise and problems

Por Silber, John R., Bobola, Michael S., Blank, A., Chamberlain, Marc C.
Publicado em 2012

Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide

Por Bobola, Michael S., Kolstoe, Douglas D., Blank, A., Chamberlain, Marc C., Silber, John R.
Publicado em 2012

Nanoparticle-mediated target delivery of TRAIL as gene therapy for glioblastoma

Por Wang, Kui, Kievit, Forrest M., Jeon, Mike, Silber, John R., Ellenbogen, Richard G., Zhang, Miqin
Publicado no Adv Healthc Mater (2015)

Culture on three-dimensional chitosan-hyaluronic acid scaffolds enhances stem cell marker expression and drug resistance in human glioblastoma cancer stem cells

Por Wang, Kui, Kievit, Forrest M., Erickson, Ariane E., Silber, John R., Ellenbogen, Richard G., Zhang, Miqin
Publicado no Adv Healthc Mater (2016)

Towards use of MRI-guided ultrasound for treating cerebral vasospasm

Por Bonow, Robert H., Silber, John R., Enzmann, Dieter R., Beauchamp, Norman J., Ellenbogen, Richard G., Mourad, Pierre D.
Publicado no J Ther Ultrasound (2016)

Apurinic/Apyrimidinic Endonuclease Is Inversely Associated with Response to Radiotherapy in Pediatric Ependymoma

Por Bobola, Michael S., Jankowski, Pawel, Gross, Mary E., Schwartz, Jeffery, Finn, Laura S., Blank, A., Ellenbogen, Richard G., Silber, John R.
Publicado em 2011

pH-Sensitive O6-Benzylguanosine Polymer Modified Magnetic Nanoparticles for Treatment of Glioblastomas

Por Stephen, Zachary R, Gebhart, Rachel N., Jeon, Mike, Blair, Allison A., Ellenbogen, Richard G, Silber, John R, Zhang, Miqin
Publicado no Bioconjug Chem (2016)

Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro

Por Kievit, Forrest M., Wang, Freddy Y., Fang, Chen, Mok, Hyejung, Wang, Kui, Silber, John R., Ellenbogen, Richard G., Zhang, Miqin
Publicado em 2011

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain

Por Taylor, Sean D, Ericson, Nolan G, Burton, Joshua N, Prolla, Tomas A, Silber, John R, Shendure, Jay, Bielas, Jason H
Publicado em 2014

Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ‐irradiation

Por Kievit, Forrest M., Stephen, Zachary R., Wang, Kui, Dayringer, Christopher J., Sham, Jonathan G., Ellenbogen, Richard G., Silber, John R., Zhang, Miqin
Publicado no Mol Oncol (2015)

O(6)-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma

Por Bobola, Michael S., Alnoor, Mohammad, Chen, John Y.-S., Kolstoe, Douglas D., Silbergeld, Daniel L., Rostomily, Robert C., Blank, A., Chamberlain, Marc C., Silber, John R.
Publicado no BBA Clin (2014)

Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds

Por Kievit, Forrest M., Florczyk, Stephen J., Leung, Matthew C., Wang, Kui, Wu, Jennifer D., Silber, John R., Ellenbogen, Richard G., Lee, Jerry S.H., Zhang, Miqin
Publicado em 2014

Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O(6)-Benzylguanine to Brain Tumors

Por Stephen, Zachary R., Kievit, Forrest M., Veiseh, Omid, Chiarelli, Peter A., Fang, Chen, Wang, Kui, Hatzinger, Shelby J., Ellenbogen, Richard G., Silber, John R., Zhang, Miqin
Publicado em 2014

Synthesis and Characterization of DNA Minor Groove Binding Alkylating Agents

Por Iyer, Prema, Srinivasan, Ajay, Singh, Sreelekha K., Mascara, Gerard P., Zayitova, Sevara, Sidone, Brian, Fouquerel, Elise, Svilar, David, Sobol, Robert W., Bobola, Michael S., Silber, John R., Gold, Barry
Publicado em 2012

TWIST is Expressed in Human Gliomas and Promotes Invasion

Por Elias, Maria C, Tozer, Kathleen R, Silber, John R, Mikheeva, Svetlana, Deng, Mei, Morrison, Richard S, Manning, Thomas C, Silbergeld, Daniel L, Glackin, Carlotta A, Reh, Thomas A, Rostomily, Robert C
Publicado em 2005

Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy

Por Mikheev, Andrei M., Ramakrishna, Rohan, Stoll, Elizabeth A., Mikheeva, Svetlana A., Beyer, Richard P., Plotnik, David A., Schwartz, Jeffrey L., Rockhill, Jason K., Silber, John R., Born, Donald E., Kosai, Yoshito, Horner, Philip J., Rostomily, Robert C.
Publicado em 2012

TWIST1 promotes invasion through mesenchymal change in human glioblastoma

Por Mikheeva, Svetlana A, Mikheev, Andrei M, Petit, Audrey, Beyer, Richard, Oxford, Robert G, Khorasani, Leila, Maxwell, John-Patrick, Glackin, Carlotta A, Wakimoto, Hiroaki, González-Herrero, Inés, Sánchez-García, Isidro, Silber, John R, Horner, Philip J, Rostomily, Robert C
Publicado em 2010

Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes

Por Kumar, Akash, Boyle, Evan A, Tokita, Mari, Mikheev, Andrei M, Sanger, Michelle C, Girard, Emily, Silber, John R, Gonzalez-Cuyar, Luis F, Hiatt, Joseph B, Adey, Andrew, Lee, Choli, Kitzman, Jacob O, Born, Donald E, Silbergeld, Daniel L, Olson, James M, Rostomily, Robert C, Shendure, Jay
Publicado no Genome Biol (2014)