Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy

Increasing age is the most robust predictor of greater malignancy and treatment resistance in human gliomas. However, the adverse association of clinical course with aging is rarely considered in animal glioma models, impeding delineation of the relative importance of organismal versus progenitor ce...

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Bibliographic Details
Main Authors: Mikheev, Andrei M., Ramakrishna, Rohan, Stoll, Elizabeth A., Mikheeva, Svetlana A., Beyer, Richard P., Plotnik, David A., Schwartz, Jeffrey L., Rockhill, Jason K., Silber, John R., Born, Donald E., Kosai, Yoshito, Horner, Philip J., Rostomily, Robert C.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504614/
https://ncbi.nlm.nih.gov/pubmed/22958206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12004
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