Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism

Although neurogenesis occurs in discrete areas of the adult mammalian brain, neural progenitor cells (NPCs) produce fewer new neurons with age. To characterize the molecular changes that occur during aging, we performed a proteomic comparison between primary-cultured NPCs from the young adult and ag...

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Detalhes bibliográficos
Main Authors: Stoll, Elizabeth A., Cheung, Willy, Mikheev, Andrei M., Sweet, Ian R., Bielas, Jason H., Zhang, Jing, Rostomily, Robert C., Horner, Philip J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207440/
https://ncbi.nlm.nih.gov/pubmed/21900249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252171
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