Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism

Although neurogenesis occurs in discrete areas of the adult mammalian brain, neural progenitor cells (NPCs) produce fewer new neurons with age. To characterize the molecular changes that occur during aging, we performed a proteomic comparison between primary-cultured NPCs from the young adult and ag...

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Hlavní autoři: Stoll, Elizabeth A., Cheung, Willy, Mikheev, Andrei M., Sweet, Ian R., Bielas, Jason H., Zhang, Jing, Rostomily, Robert C., Horner, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207440/
https://ncbi.nlm.nih.gov/pubmed/21900249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252171
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